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Auflistung Nach Schlagwort "molecular pathology"

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    • Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease 

      Siokas V., Stamati P., Pateraki G., Liampas I., Aloizou A.-M., Tsirelis D., Nousia A., Sgantzos M., Nasios G., Bogdanos D.P., Dardiotis E. (2022)
      A few gene loci that contribute to Alzheimer’s Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent ...

    • Anti-hsp60 antibody responses based on Helicobacter pylori in patients with multiple sclerosis: (ir)Relevance to disease pathogenesis 

      Efthymiou G., Dardiotis E., Liaskos C., Marou E., Tsimourtou V., Scheper T., Meyer W., Daponte A., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P. (2016)
      In view of published data suggesting that Helicobacter pylori (Hp) is a trigger of multiple sclerosis (MS), we assessed anti-heat shock protein 60 (hsp60)Hp antibody reactivity in 129 MS patients and 48 demograpically-matched ...

    • The emerging role of helicobacter pylori-induced metabolic gastrointestinal dysmotility and neurodegeneration 

      Kountouras J., Boziki M., Polyzos S.A., Katsinelos P., Gavalas E., Zeglinas C., Tzivras D., Romiopoulos I., Giorgakis N., Anastasiadou K., Vardaka E., Kountouras C., Kazakos E., Giartza-Taxidou E., Deretzi G., Dardiotis E., Kotronis G., Doulberis M. (2017)
      Helicobacter pylori infection (Hp-I) is a prevalent disorder identified in themajority of the population in many countries around the world and is responsible for substantial gastrointestinal morbidity. Likewise, ...

    • Expression profile of the GA733 gene family in colorectal cancer: Correlation with clinicopathological parameters 

      Mamaloudis I., Zacharoulis D., Samara M., Papadopoulos G., Samara S., Koukoulis G., Chatzitheofilou C., Kollia P. (2015)
      GA733-1/-2/-3 genes have been detected in various types of cancer, although their role has not been fully clarified. GA733-2 and GA733-1 have been correlated with lymph node metastases in laryngeal cancer and liver metastases, ...

    • Familial partial lipodystrophy (FPLD): Recent insights 

      Bagias C., Xiarchou A., Bargiota A., Tigas S. (2020)
      Lipodystrophies are a heterogeneous group of congenital or acquired disorders, characterized by partial or generalized loss of adipose tissue. Familial partial lipodystrophy (FPLD) presents with genetic and phenotypic ...

    • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis 

      Schormair B., Zhao C., Bell S., Tilch E., Salminen A.V., Pütz B., Dauvilliers Y., Stefani A., Högl B., Poewe W., Kemlink D., Sonka K., Bachmann C.G., Paulus W., Trenkwalder C., Oertel W.H., Hornyak M., Teder-Laving M., Metspalu A., Hadjigeorgiou G.M., Polo O., Fietze I., Ross O.A., Wszolek Z., Butterworth A.S., Soranzo N., Ouwehand W.H., Roberts D.J., Danesh J., Allen R.P., Earley C.J., Ondo W.G., Xiong L., Montplaisir J., Gan-Or Z., Perola M., Vodicka P., Dina C., Franke A., Tittmann L., Stewart A.F.R., Shah S.H., Gieger C., Peters A., Rouleau G.A., Berger K., Oexle K., Di Angelantonio E., Hinds D.A., Müller-Myhsok B., Winkelmann J., Balkau B., Ducimetière P., Eschwège E., Rancière F., Alhenc-Gelas F., Gallois Y., Girault A., Fumeron F., Marre M., Roussel R., Bonnet F., Bonnefond A., Cauchi S., Froguel P., Cogneau J., Born C., Caces E., Cailleau M., Lantieri O., Moreau J.G., Rakotozafy F., Tichet J., Vol S., Agee M., Alipanahi B., Auton A., Bell R.K., Bryc K., Elson S.L., Fontanillas P., Furlotte N.A., Hinds D.A., Hromatka B.S., Huber K.E., Kleinman A., Litterman N.K., McIntyre M.H., Mountain J.L., Northover C.A., Pitts S.J., Sathirapongsasuti J.F., Sazonova O.V., Shelton J.F., Shringarpure S., Tian C., Tung J.Y., Vacic V., Wilson C.H., 23andMe Research Team, DESIR study group, 23andMe Research Team, DESIR study group, DESIR study group, DESIR study group (2017)
      Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve ...

    • Insights into the molecular etiology of exercise-induced inflammation: Opportunities for optimizing performance 

      Fatouros I.G., Jamurtas A.Z. (2016)
      The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also because it is an excellent model to study the mechanisms governing muscle cachexia ...

    • Left ventricular hypertrophy and sudden cardiac death 

      Giamouzis G., Dimos A., Xanthopoulos A., Skoularigis J., Triposkiadis F. (2022)
      Sudden cardiac death (SCD) is among the leading causes of death worldwide, and it remains a public health problem, as it involves young subjects. Current guideline-directed risk stratification for primary prevention is ...

    • Managing Viral Emerging Infectious Diseases via current Molecular Diagnostics in the Emergency Department: the Tricky Cases 

      Mouliou D.S. (2022)
      Introduction: Emerging infectious diseases’ diagnosis has been a major problem in most hospitals and other senior care facilities, especially for the current Coronavirus Disease 2019 (COVID-19). The various clinical ...

    • Meta-analysis of gene expression data in adipose tissue reveals new obesity associated genes 

      Goutzelas Y., Kontou P., Mamuris Z., Bagos P., Sarafidou T. (2022)
      High-throughput transcriptomic and proteomic data like microarray data are deposited in public databases such as Gene Expression Omnibus (GEO). Omics data integration and processing from different and independent studies ...

    • Molecular investigation and geographical distribution of Leishmania spp infection in stray and owned cats (Felis catus) in Thessaly, central Greece 

      Giannakopoulos A., Tsokana C.N., Papadopoulos E., Spyrou V., Chatzopoulos D.C., Valiakos G., Touloudi A., Athanasiou L.V., Billinis C. (2017)
      In this study we aimed to determine the prevalence of Leishmania spp infection and to report the geographical distribution of Leishmania spp infected cats from Thessaly, central Greece, an endemic region for canine and ...

    • The prognostic significance of the Hedgehog signaling pathway in colorectal cancer 

      Papadopoulos V., Tsapakidis K., Riobo Del Galdo N.A., Papandreou C.N., Del Galdo F., Anthoney A., Sakellaridis N., Dimas K., Kamposioras K. (2016)
      Despite significant advances in the management of colorectal cancer (CRC) the identification of new prognostic biomarkers continues to be a challenge. Since its initial discovery, the role of the Hedgehog (Hh) signaling ...

    • The role of the NLRP3 inflammasome and the activation of IL-1β in the pathogenesis of chronic viral hepatic inflammation 

      Molyvdas A., Georgopoulou U., Lazaridis N., Hytiroglou P., Dimitriadis A., Foka P., Vassiliadis T., Loli G., Phillipidis A., Zebekakis P., Germenis A.E., Speletas M., Germanidis G. (2018)
      Background and aims: Chronic viral hepatitis is a prevalent disease with major health implications. Its underlying pathophysiological mechanisms are not fully understood. IL-1β and the NLRP3 inflammasome involvement has ...

    • Sensitivity and applications of the PCR Single-Strand Conformation Polymorphism method 

      Kakavas K.V. (2021)
      PCR Single-Strand Conformation Polymorphism is a method used to identify and detect mutations and is now well known for its many applications on living beings. This paper will discuss the experimental details, limitations ...

    • Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index 

      Hartley A., Sanderson E., Granell R., Paternoster L., Zheng J., Smith G.D., Southam L., Hatzikotoulas K., Boer C.G., Van Meurs J., Zeggini E., Gregson C.L., Tobias J.H., Stefánsdóttir L., Zhang Y., De Almeida R.C., Wu T.T., Teder-Laving M., Skogholt A.-H., Terao C., Zengini E., Alexiadis G., Barysenka A., Bjornsdottir G., Gabrielsen M.E., Gilly A., Ingvarsson T., Johnsen M.B., Jonsson H., Kloppenburg M.G., Luetge A., Mägi R., Mangino M., Nelissen R.R.G.H.H., Shivakumar M., Steinberg J., Takuwa H., Thomas L., Tuerlings M., Babis G., Cheung J.P.Y., Samartzis D., Lietman S.A., Slagboom P.E., Stefansson K., Uitterlinden A.G., Winsvold B., Zwart J.-A., Sham P.C., Thorleifsson G., Gaunt T.R., Morris A.P., Valdes A.M., Tsezou A., Cheah K.S.E., Ikegawa S., Hveem K., Esko T., Wilkinson J.M., Meulenbelt I., Michael Lee M.T., Styrkársdóttir U. (2022)
      Objectives: Observational analyses suggest that high bone mineral density (BMD) is a risk factor for osteoarthritis (OA); it is unclear whether this represents a causal effect or shared aetiology and whether these relationships ...